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Journal of Scientific and Technical Research

Issue 1, 2024

Original Articles
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Recent Developments in N,S,O Donor Schiff Base Molecules as Anti-Cancer Therapeutics
Misbah Shahid and Preeti Jain*
Abstract
Biological importance in many fields, including anti-cancer activity, and advances in inorganic chemistry with biological applications have heightened the scope of interest in Schiff bases and their complexes due to the combination of an aldehyde with an amine are useful chelate to produce coordination spheres with mixed N/O donors. The discovery of Schiff base and its complexes’ antitumor activity against various tumor cell lines captures the interest of researchers seeking to develop new anti-cancer drugs with no side effects. O-vanillin is a very useful aldehyde for preparing Schiff base ligands. It is found in the extract of vanilla. It is readily soluble in water. This aldehyde can combine with several different types of amine to form Schiff base which can form complexes with high stability with the majority of metals, which is caused by the azomethine group’s nitrogen (N) in addition to two oxygen (O) atoms from the hydroxyl and methoxy groups. Apoptosis is a natural death process of damaged, senescent, or abnormal cells that stops cancer development. It is reduced or blocked in cancer cells and can be triggered again by anti-cancer drugs. Therefore, in anti-cancer research, inducing cancer cell apoptosis is a favourable goal to be achieved by a new molecule blocked in cancer cells and can be triggered again by anti-cancer drugs. This review focuses on recent advances in N,S,O donor Schiff base molecules for Anti-cancer applications.
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Pollutant Removal from Water by Polymer Nanocomposites as Adsorbents - A Review
Alka Singh1, Richa Tomar1* and N. B. Singh1,2*
Abstract
Polymer nanocomposites have emerged as a pivotal solution to contemporary environmental challenges due to their remarkable ability to address issues such as greenhouse gas emissions reduction and wastewater contamination. The integration of innovative nanomaterials like nanoparticles, carbon nanotubes, nanofibers, and activated carbon into polymers has spurred the development of transformative nanotechnologies for wastewater treatment. These advancements offer substantial benefits in terms of pollutant removal, particularly heavy metals, dyes, and oils from wastewater. The utilization of polymer nanocomposites has facilitated rapid decontamination processes with high selectivity for a wide range of contaminants. This comprehensive review highlights the significant role of polymer nanocomposites in effectively removing metal ions, dyes, and microorganisms from polluted water sources. Through synergistic interactions between the polymer matrix and nanomaterials, these composites exhibit enhanced adsorption capacities and efficient pollutant sequestration, contributing to the mitigation of environmental pollution and safeguarding water resources for sustainable development.
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Epistemological and Psychosomatic Analyses of Trauma
Zeba Munib1and Sher Ali2*
Abstract
Trauma has profoundly impacted human beings for centuries. There are a number of reasons behind any traumatic event. Trauma is not only a medical, pathological, or psychological condition or state, but it is also ontological, epistemological, and cultural ones. It defies a clear and perceptible understanding, as it is beyond the realm of epistemic frameworks. This paper explores the nuances of trauma on individuals, examining its origins and manifestations through the conceptual frameworks of prominent trauma theorists Catherine Malabou and Cathy Caruth. We have used modern and contemporary fictions encompassing the works of Saadat Hasan Manto, Katherine Mansfield, Razia Butt, Virginia Woolf, Lisa Genova, Preeti Shenoy, and Franz Kafka. They have covered multifaceted nature of trauma, encompassing medical, psychological, ontological, epistemological, and cultural dimensions. By examining various aspects of trauma within the context of these literary works, the paper seeks to provide a deeper understanding of this complex phenomenon.
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A Review of the Recall Process for Failing Medications in the Pharmaceutical Industry
Vasundhara Saxena1*, Adarsh Tomar1, Vikas Sharma2, and Rahul Kaushik3
Abstract
The pharmaceutical industry plays a pivotal role in public health by providing essential medications. However, flawed medications can have severe consequences for patients and healthcare systems. This article provides a thorough examination of the process and implications of recalling flawed medications. It delves into the various challenges faced by pharmaceutical companies, regulators, and healthcare professionals in identifying and addressing medication flaws. The article also discusses the significant consequences of medication recalls, including potential harm to patients, financial burdens, and damage to a company’s reputation. Furthermore, it explores innovative solutions and strategies to minimize the occurrence of medication recalls and streamline the recall process when necessary. By shedding light on this critical aspect of the healthcare industry, this article aims to contribute to a safer and more effective medication supply chain, ultimately ensuring the well-being of patients and the integrity of the pharmaceutical sector.
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Sensory Profiling and Consumer Preference Analysis of Dark Chocolate Enriched with Algal Oil: A Comprehensive Evaluation
Divita Jain¹, Bushra Shaida², and Akansha³*
Abstract
In terms of sustainable and equitable food security, the world is experiencing a number of issues due to the rapid increase in population. Given their fast growth rates and ability to survive in non-arable terrain, microalgae are seen to be one of the most promising feedstocks for a sustainable and reasonably priced supply of food and fuel. Algae being a rich and reliable source of fatty acid especially Omega-3. It was decided to create a dark chocolate with 12, 14, 16, and 18% algae inclusion. As the goods’ amount of algal oil increased, so did their concentration of omega-3 fatty acids. The food industry is now experiencing a dramatic uptick in the new products, improved quality, increased productivity, decreased production, and distribution costs, increased shelf life, and increased competition as a result of the gradual elimination of trade barriers and the expansion of global markets. Success in the face of these new challenges will depend heavily on the industry’s capacity to get more precise information about consumer perceptions and attitudes that pertain to food items, and the most effective ways to quantify and apply them. The first stage in doing it is sensory evaluation. The product containing 18% algal oil had a more pronounced fishy taste and a stronger aroma. Ninety-two percent of the sensory panel approved of the chocolate containing algae oil. Every sample had an acceptability index more than 70%. At the amounts examined in this study, algae oil might be added to the dark chocolate to enhance any potential health advantages.
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Coronavirus Pandemic: Clear and Present Danger
Anam Farooqui¹, Farha Bano², and Sher Ali³*
Abstract
Scientists, clinicians, health care personnel and policy makers were all taken aback with a sudden spurt of Coronavirus pandemic that had impacted every nation raising many issues related to the life of a common man. Now, the impact of the pandemic has subsided and people have resumed their routine. However, the present situation should not be taken to be the reason for complacency. Instead, we must be prepared to face this or similar challenges in future. A wrong decision taken in one country has its far-reaching consequences world over. One has seen the ever-mounting death toll in some countries for their delayed or incorrect decisions. Clearly, we need to understand the virulency of the Coronavirus and its biology in the context of herd immunity, symptomatic and asymptomatic cases, resistant and susceptible genomes and human immune system. In addition, comorbidity has its own impact on the human genome which not only makes a person more susceptible but less responsive to the medications. The electronic media has now become a double edge sword, not knowing its own limit, disregarding the effect of unedited or poorly edited news focusing only on its target rating point (TRP). Thus, along with relevant information, several wrong ones are also propagated. Too much incorrect news does not allow us to use our judicious prerogative. Further, the blame game makes the job of caregivers a lot more complicated. The other dimension of the present peril is that several African countries, though have modest amounts of money to buy medicine, masks, and protective gear, were not allowed to do so because of the International Sanctions. The circumstances dictated us to use all our resources to contain this pandemic and be on the same page. Promulgation of lockdown was an attractive option but not without its severe consequences. Taiwan had managed this pandemic very well without a lockdown, as did Sweden and New Zealand. However, timely lockdowns in the UK and USA would have saved many lives. These instances are contradictory and call for due deliberation. Thus, each country has to evolve its own strategy keeping in view the local dynamics and long-term perspectives. Present overview is aimed to provide a judicious mix of critical information in a semi-scientific manner highlighting the ground realities faced by the common people including the logistics used by the government machinery to contain this pandemic. This article also covers social, financial, emotional aspects and problems faced by the caregivers and law enforcement agencies. During the COVID-19 pandemic, civility of the highest order and greed of the worst kind both were witnessed. We need to fine-tune our civility and act as responsible global citizens avoiding superstition and complacency, not blaming anyone for anything, and extending our helping hand to others as much as possible. Even now, we must be prepared to face the aftermath of this pandemic and to undertake an uphill task of rebuilding the society, nations and the world.
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Modification and Application of Starch Acquired by Industrial Waste
Shalvika Tripathi¹, Akansha²*, and Bushra Shaida³
Abstract
Fruits are a staple of many diets and are consumed in large quantities. Additionally, the world population is expanding and dietary changes have increased demand for this product, which has led to an increase in waste. In addition, a large amount of waste is produced during the processing of fruit, including juice processing, pulp extraction, jams, and frozen pulp. Skin, pulp, seed debris, and pomace are examples of wastes that are rich in substances with added value, such as starch. One of the most prevalent biodegradable polymers in nature, starch finds extensive application in the food and beverage, bioplastic, paper, textile, and biofuel industries. Because of its low toxicity, facile synthesis, relative abundance, and biodegradability, starch has drawn a lot of interest. Starch is made up of amylose and amylopectin. However, because of its increased water absorptivity and poor thermo-mechanical qualities, natural starch cannot be employed directly. As a result, native starch requires modification prior to usage. The main methods for modifying starch are enzymatic, chemical, and physical. Chemical alteration techniques are among the most widely used in enterprises. The chemical starch modification approaches as well as the physical and enzymatic that have been developed in the last few years are covered in detail in this study. Furthermore, the present-day uses of modified starch have been examined in the domains of superabsorbent, packaging, adhesives, medicines, and widely used in food industries.
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Effects of Heavy Metals on Renal Function: A Mini Review
Achala Dwivedi1, Shrisha Singhania1and Prashant Agrawal2*
Abstract
This extensive study provides a synopsis of the kidney health effects of lead, cadmium, and arsenic. Kidney damage is caused by these metals. These include oxidative injury, inflammation, and structural deterioration of renal tissue. These processes involve complex molecular and cellular pathways. Metals that exhibit synergistic effects elevate the likelihood of nephrotoxicity and a decline in renal function. The function of environmental exposure and the significance of interaction effects in chronic renal diseases are illuminated by regional studies. Analyses of the response to exposure to nephrotoxic metals indicate that they induce kidney stones and severe renal complications. Strategies for stratifying populations illustrate the intricate relationship between exposure patterns and a variety of health outcomes. Due to the severe health effects of heavy metal exposure, stringent monitoring and control measures are required to mitigate health hazards. Subsequent research ought to concentrate on the cumulative impacts of heavy metals, early indicators of nephrotoxicity, and remedies based on regional exposure patterns. Each duty ought to be completed. Our results establish a fundamental basis for public health interventions aimed at safeguarding the renal well-being of a heterogeneous populace in light of the enduring peril of heavy metal exposure.
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Heavy Metal Accumulation in Vegetables, Water and Soil in Different Regions of India - A Review
Shrisha Singhania Achala Dwivedi Prashant Agrawal
Abstract
Environmental contamination caused by heavy metals resulting from fast economic expansion and inappropriate waste and wastewater management is a big problem. Expansion in industry and urbanisation, along with population expansion, resulted in a rise in sewage discharge in cities and towns. Many small-scale farmers in urban and semi-urban areas in developing nations rely on urban streams to irrigate crops and vegetables. As a result, the toxins in wastewater represent a significant risk to both flora and wildlife. Depleting fresh water supplies causes a rise in the use of wastewater for irrigation, which eventually packs hazardous metals into soil and enters the food supply via vegetables and agricultural produce. Food safety is of the utmost importance to the people since it is the primary source of sustenance. There are three basic pathways for human exposure to pollutants: inhalation, absorption, and ingestion. Ingestion accounts for 90% of exposure when matched to other means of toxicity. As a result, contaminants in wastewater pose a substantial threat to both plants and wildlife. Depleting fresh water resources leads to an increase in the utilisation of wastewater for agriculture, which eventually packs harmful metals into soil and penetrates the chain of food through crops and agricultural products. Food safety is extremely important to individuals since it is their major source of nutrition. Human exposure to contaminants occurs through three fundamental pathways: inhalation, absorption, and ingestion. When compared to other modes of toxicity, ingestion represents 90% of total exposure.
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The Intersection of Artificial Intelligence and Climate Science: Opportunities and Risks in Global Governance
Simran¹, Tapan Biswal²*
Abstract
This paper aims to analyse the relationship that exists between artificial intelligence (AI) and climate science, focusing on the opportunities and the risks that new technologies could open up for global governance. This research seeks to review how AI technologies can help solve climate change challenges effectively and how they can be harnessed with an eye on the potential risks and ethical considerations in implementation in global governance frameworks. The approach used in this study is through literature review, case studies, interviews of experts, and analysis of the policies developed that find the increasing tendency of utilization of AI applications in climate science from climate modelling to data analysis, predictive analysis, and policy recommendation. Key findings of the study underline the great opportunities that AI can create toward bettering climate resilience, mitigation, and adaptation strategies. AI would also have a great contribution to supporting the governance of the climate for evidence-based decision-making. Moreover, the research also highlights risks and challenges of how AI is used in global governance: concerns related to privacy, data protection, algorithmic biases, transparency, accountability, and socio-economic impacts. These, therefore, have far-reaching implications for policymakers, researchers, and other stakeholders in climate governance that point to the necessity of ethical AI frameworks, regulatory measures, international cooperation, and interdisciplinary approaches so that the benefits and the associated risks to AI are minimized.
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Optogenetic - Treatment of Parkinson Disease and Challenges Ahead
Bhagyashree Dubey and Yogesh Tripathi
Abstract
Optogenetic tools with photosensitive opsins and LEDs enable precise spatial and temporal neural control to study neurodegenerative disorders, especially Parkinson’s Disease (PD). Research highlights the role of optogenetics in understanding basal ganglia circuitry, the direct and indirect pathways, and the molecular basis of PD, including -synuclein aggregation and dopaminergic neuron loss. The 6-OHDA model is frequently manipulated via optogenetics to study this loss, and high-frequency optical stimulation shows potential in ameliorating PD motor symptoms like bradykinesia and hypokinesia. Furthermore, researchers are using optogenetic modulation to study conventional PD treatments, such as deep brain stimulation and Levodopa, to better understand underlying circuitry mechanisms of PD.
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Impact of Faradic Foot Bath Application in Lisfranc Injury: A Case Report
Pooja Singh1, Manish Kumar1and Archana Khanna2*
Abstract
Lisfranc injuries involve damage to the foot's complex ligament structure, typically causing severe pain, limited mobility, and reduced proprioception. This case report focuses on a 40-year-old patient with persistent, severe midfoot pain following a twisting accident, which did not resolve with standard orthopaedic management. The study highlights that a two-week application of faradic foot baths combined with joint mobilization led to significant pain reduction and improved functionality.
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"Improvement in Multiferroic and Photocatalytic Properties of Bismuth Ferrite Nanoparticles: A Review"
Adil Hamid, Mohit Sahni , and Aarti Gupta
Abstract
"BiFeO3 (BFO) is the most promising of this rare ABO3-type perovskite multiferroic materials because it exhibits in bulk BFOs with high ferroelectric Curie temperatures TC 1103 K and G-type antiferromagnetic Neels TN 643 K, multiferroic behavior can be observed at room temperature. It is lead-free, possesses fascinating multiferroic and optical properties, and is environmentally benign. Recent investigations on BFO have shown that it forms an excellent visible light-responsive photo-catalytic material due to its band gap of 2 eV and the remarkable stability of chemicals. In this manuscript we have tried to explain the improvement in the multiferric and photocatalytic properties of BFO by substitution on A and B site. The various synthesis processes along with their impact, the types of doping and their impact on the structural changes and thereafter these impact results in the improvement in the properties has been explored in the manuscript."
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